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KMID : 0043320070300121501
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Archives of Pharmacal Research
2007 Volume.30 No. 12 p.1501 ~ p.1506
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Synthesis of N-phenylphthalimide Derivatives as α-Glucosidase Inhibitors
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Pluempanupat Wanchai
Chavasiri Warinthorn
Adisakwattana Sirichai
Yibchok-Anun Sirintorn
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Abstract
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Sixteen N-phenylphthalimide derivatives were synthesized and their ability to inhibit α-glucosidase was investigated. N-(2,4-dinitrophenyl)phthalimide was a potent inhibitor of yeast α-glucosidase (IC50; 0.158 ± 0.005 mM) and maltase (IC50; 0.051 ± 0.008 mM), whereas it did not inhibit sucrase. From a Lineweaver-Burk plot of α-glucosidase kinetics, N-(2,4-dichlorophenyl) phthalimide was found to be a competitive inhibitor of yeast α-glucosidase. These results indicate that N-(2,4-dinitrophenyl)phthalimide could be a representative of a new group of α- glucosidase inhibitors
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KEYWORD
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N-Phenylphthalimide, α-Glucosidase, Diabetes
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